The next step for Burkitt lymphoma
نویسندگان
چکیده
منابع مشابه
The next step for Burkitt lymphoma
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The successes in the treatment of childhood acute lympho-blastic leukemia (ALL) are well known, with a cure rate of more than 80% of patients treated. However, for the minority of patients who fail to achieve long-term remission, treatment options are limite...
متن کاملSporadic Burkitt Lymphoma: A Case Report
Introduction: Burkitt lymphoma is an aggressive subtype of Hodgkin lymphoma with a doubling time of 25 hours. It is characterized by a MYC gene coding alteration which results from a translocation of chromosome 8 on the MYC gene locus and immunoglobulin heavy-chain locus (IGH) on chromosome 14. Even though HIV infection is associated to an increased risk of Burkitt lymphoma, th...
متن کاملBurkitt Lymphoma in the Mouse
Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Ig kappa) or lambda (Ig lambda) L chain genes and effecting deregulated expression of MYC are the hallmarks of human Burkitt lymphoma (BL). Here we report that lymphomas with striking similarities to BL develop in mice bearing a mutated human MYC gene controlled by a r...
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Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
متن کاملDiagnosis of Burkitt Lymphoma
Clinical presentation in extranodal and nodal sites of rapidly expanding masses in high-risk populations suggests Burkitt lymphoma (BL). Most patients present with advanced disease because of the rapid rate of tumor growth. BL cells have a remarkably short doubling time. Children in equatorial Africa and Papua New Guinea have endemic BL and present with facial tumors in the jaw or orbit, abdomi...
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ژورنال
عنوان ژورنال: The Korean Journal of Hematology
سال: 2011
ISSN: 1738-7949
DOI: 10.5045/kjh.2011.46.2.60